6th International Conference on Rare Diseases and Orphan Drug

Gigantism Gigantism also called gigantism obtained from a Greek word gigas, is a Rare Endocrine Diseases characterized by excessive growth hormone which accelerates the growth of muscle, bones and connective tissue in childhood or youth before the end of puberty. It is always the consequence of a growth hormone secreting pituitary tumour. When left untreated or uncontrolled, some individuals suffering from gigantism have grown in excess of eight feet (2.4 m) tall. The most well-known example is that of Robert Wadlow, the tallest person in history. Cause Most common reason of gigantism is Pituitary gland tumor . The pea sized pituitary gland is located at the base of the brain; it makes hormones that control body temperature, metabolism growth, sexual development and urine production. Some other cause of gigantism is: ·          McCune-Albright disease is a disorder that causes unusual growth of bone tissues, gland irregu...

Cri du chat syndrome, also known as 5p minus  / 5p deletion syndrome or Lejeune syndrome, which is a type of rare genetic disorder . It is originated from a French term cat which means cry or call of the cat, referring to the characteristic cat like cry of affected children. This disorder is characterized by intellectual disability and late growth, low birth weight, little head measure, weak muscle tone in early stages and typical facial features. While it is a hereditary condition, most cases are not acquired. It is found in all ethnic backgrounds and is more common in females by 4:3 ratios. Jerome Lejeune, a geneticist, was discovered this in 1963. In 80% of the cases, the affected chromosome comes from the father’s sperm rather than the mother’s egg. Cause Cri du chat is one of the most common syndromes caused by deletion of the short arm of chromosome 5. This chromosomal change is written as 5p-. The size of deletion varies among affected individuals. It is possib...

Prostate cancer is a type of Rare Oncology Disease , caused by mutations in your DNA, or genetic material, lead to the growth of cancerous cells. DNA is the biological in our cells that makes up our genes. Our genes regulate our cells function. These mutations cause cells in your prostate to start growing uncontrollably and unusually. Abnormal or cancerous cells continue to grow and divide until a tumour develops. Symptoms Due to the closeness of the prostate gland in relation to the bladder and urethra,  prostate cancer  may be accompanied by a variety of urinary symptoms. Some prostate cancer signs related to urination include: §   Burning or pain during urination §   Difficulty urinating, or trouble starting and stopping while urinating §   More frequent urges to urinate at night §   Loss of bladder control §   Decreased flow or velocity of urine stream §   Blood in urine (hematuria) Prostate cancer might spread...

Sjogren's syndrome is a type of Rare Oral Diseases . It is an autoimmune disorder that can happen at any age yet is most normal in older women. Numerous patients build up Sjogren's syndrome as a complication of another autoimmune disease for example rheumatoid arthritis or lupus. Most patients with Sjogren's syndrome remain healthy, but some rare complications have been defined, including an increased risk for cancer of the lymph glands (lymphoma). Thus, regular medical care and follow up is significant for all patients. This can affect many different parts of the body, but mostly often affects the tear and saliva glands. Patients with this condition may notice irritation, a realistic feeling, or painful sweltering in the eyes. Dry mouth (or difficulty eating dry foods) and puffiness of the glands around the face and neck are likewise normal. Some patients experience dryness in the nasal openings, throat, vagina and skin. Swallowing trouble and symptoms of ac...

Cannabinoids are synthetic substances correlated to  delta-9-tetrahydrocannabinol  (THC), marijuana’s main modifying ingredient that makes people "high." The marijuana plant contains more than 100 cannabinoids.  A manufactured cannabis drug used to treat nausea in cancer patients may also help calm anxiety in patients with Alzheimer’s disease. Anxiety is one of the most troubling symptoms of Alzheimer’s, and can be difficult to manage. It’s the reason some dementia patients are given antipsychotic drugs or even physically restrained, steps that go against medical advice. Sedatives, anxiety drugs and other medications are also often given to patients. Anxiety, aggression, sleep disturbances — all have a significant impact on both their quality of life and their carers’ quality of life. The body additionally produces its own cannabinoid synthetic compounds . Some of these cannabinoids are extremely powerful and have directed to serious health effects when di...