6th International Conference on Rare Diseases and Orphan Drug

The effect of sleep deprivation and disruption on DNA damage DNA damage and repair are dynamic processes that may be affected by various conditions and cellular events. Animal studies have shown that sleep loss can induce genetic damage in different organs. Sleep deprivation is known to induce oxidative stress, and there is increasing interest in genomic changes related to sleep deprivation. The way people’s genes work is altered when their body clock is interrupted. A study has shown that sleep deprivation does more harm to the human body, than imagined. According to it, sleep deprivation can affect our genes and lead to the destruction of our DNA. Damaged DNA amplified after only one night of sleep deprivation. According to the researchers, this damage may help illuminate the increased risk for cancer and cardiovascular, metabolic diseases as well as neurodegenerative disorders that are usually related with sleep deprivation. Although this work is very preliminary, it is c

High Blood Sugar during pregnancy is related with congenital heart defects, which is one of the most Rare Cardiac Disorder . Congenital heart defects or diseases are the complications with the heart’s structure that are available during childbirth. They might change the normal flow of blood through the heart. These are the most widely recognized kind of birth defect. There are various types of congenital heart defects. The most well-known defects involve the inside walls of the heart, the valves of the heart, or the large blood vessels that carry blood to and from the heart. Particular defects require no treatment, but some require treatment soon after birth. Because analysis and treatment of congenital heart defects has developed, more babies are surviving and now many adults are living with congenital heart defects.           Congenital heart disease is the (CHD) consequence of a complex relations between genetic and non-genetic, or "environmental factors working on the

Chronic Kidney Disease Chronic Kidney Disease is a Rare Diseases of Genitourinary System , & type of slow and long term condition that damage kidneys and decrease their ability to keep healthy. It is also called as chronic renal failure or chronic kidney failure. It is a common condition often associated with getting older, although it’s more common in black people of south Asian origin.  The disease is called “chronic” because the damage of kidney happens slowly over a long period of time & also this damage can cause wastes to build up in body, which also can cause other health problems. Symptoms Signs and symptoms of chronic kidney disease grow over time if kidney damage progresses slowly. Signs and symptoms of this disease may include, ·         Sleep problems ·         Decreased Mental Sharpness ·         Swelling of feet and ankels ·         Loss of appetite ·         Chest pain,if fluid builds up nearby the lining of the heart ·         Sh